MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene — one of a small group of mitochondrial-derived peptides identified in the last decade. It acts as a metabolic regulator with broad effects on insulin sensitivity, glucose homeostasis, and exercise-like adaptations.
Research has positioned MOTS-c as an endogenous "exercise mimetic" with relevance to metabolic flexibility and age-related decline. It is classified as a banned experimental peptide by WADA.
- Mitochondrial-peptide / exercise-mimetic research
- Insulin sensitivity and glucose homeostasis
- Age-related metabolic decline studies
- Inflammation and physical-performance models
- CAS
- 1627580-64-6
- MW
- 2174.6
- Formula
- C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Sequence
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Lyophilized vial stable at 2–8 °C; -20 °C for long-term storage. Reconstitute with sterile bacteriostatic water; reconstituted solution stable for up to 30 days at 2–8 °C.
For research and laboratory use only. Not for human or veterinary consumption.
How to run this compound.
Add bacteriostatic water to the sealed vial. Swirl — do not shake. Refrigerate after reconstitution.
Reconstitute with bacteriostatic water. Subcutaneous administration on protocol cadence.
Run on the protocol schedule. The system rewards consistency over intensity.
Pair with complementary REFRAME lines. See suggestions below.