System · 03 protocols active

Weight
Management

Metabolic & Body Composition

Compounds that act on the metabolic axis — GLP-1, GIP, glucagon. Where weight-loss research ends and body composition begins.

View anchor protocols →The science

Protocols

GLP-1 · GIP · Glucagon

Axis

Active

Phase

Triple-axis · neural

10mg sterile · Lot 0421

Anchor protocols

The two vials at the core of the arc.

Bestseller

RETATRUTIDE™

Retatrutide

Retatrutide (LY-3437943) is a research peptide acting as a triple-receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Studied for weight management, glucose control, and metabolic function.

Mazdutide binds GLP1R and glucagon receptors simultaneously, inducing a fasted-like metabolic state. Approved in China for obesity and type 2 diabetes (June 2025); applied weekly via injection.

$109.99

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Continuation · variants

All vials in this system.

Begin the reframe.

Most researchers enter through MAZDUTIDE. Some begin with RETATRUTIDE if they have prior arc experience.

Start with MAZDUTIDE →Begin with RETATRUTIDE

WeightManagement

The two vials at the core of the arc.

All vials in this system.

Begin the reframe.

Weight
Management