KPV is a tripeptide composed of lysine, proline, and valine — the C-terminal sequence of α-melanocyte-stimulating hormone (α-MSH). It retains the anti-inflammatory activity of its parent hormone while showing improved stability and specificity.
Its primary characterized mechanism is inhibition of the NF-κB inflammatory pathway, with additional antimicrobial activity and modulation of mucosal immunity.
- NF-κB pathway inhibition research
- Inflammatory bowel disease and gut-lining studies
- Skin inflammation (psoriasis, eczema) models
- Oxidative stress and immune-modulation research
- CAS
- 67727-97-3
- Formula
- C₁₆H₃₀N₄O₄
Lyophilized vial stable at 2–8 °C; -20 °C for long-term storage. Reconstitute with sterile bacteriostatic water; reconstituted solution stable for up to 30 days at 2–8 °C.
For research and laboratory use only. Not for human or veterinary consumption.
How to run this compound.
Add bacteriostatic water to the sealed vial. Swirl — do not shake. Refrigerate after reconstitution.
Reconstitute with bacteriostatic water. Subcutaneous administration on protocol cadence.
Run on the protocol schedule. The system rewards consistency over intensity.
Pair with complementary REFRAME lines. See suggestions below.